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San Francisco 49ers, NFL and Seattle

49ers vs. Seahawks odds: San Francisco open as one-score favorites over Seattle

The San Francisco 49ers and Seattle Seahawks will meet on Sunday at Lumen Field. Here's how the odds look heading into the matchup.

USA TODAY Sports on MSN · 3h

San Francisco 49ers at Seattle Seahawks: Predictions, picks and odds for NFL Week 1 game

USA Today's NFL experts make their picks for a Week 1 showdown between the Seattle Seahawks and San Francisco 49ers

FOX Sports on MSN · 1d

2025 San Francisco 49ers Depth Chart Heading into NFL Week 1

Explore the San Francisco 49ers’ 2025 NFL Week 1 depth chart, including projected starters, key depth options, and position battles.

1 thing Brock Purdy and the 49ers MUST improve on in 2025

Newsweek on MSN · 1h

49ers Legend Joe Montana Gives Strong Prediction for Brock Purdy

NFL legend Joe Montana shared his take on San Francisco 49ers quarterback Brock Purdy and his upcoming season.

49ers Webzone on MSN · 1h

49ers GM John Lynch reveals what makes Brock Purdy so impressive

All eyes will be on Brock Purdy this season as the San Francisco 49ers quarterback looks to prove he can live up to the five-year, $265 million contract extension he signed this offseason.

ClutchPoints · 2h

49ers’ Brock Purdy reveals massive ‘Super Bowl’ mistake last season

San Francisco 49ers quarterback Brock Purdy says one thing in particular kept him off his game during the 2024 season.

5 new Seahawks 49ers must be ready for in Week 1

Yahoo! Sports · 1d

49ers make roster move with practice squad implications before Week 1 vs. Seahawks

The San Francisco 49ers are banged up at the wide receiver position. That is well known as the 2025 regular season begins this week.

USA TODAY Touchdown Wire o… · 1d

3 potential X-factors on Seahawks defense vs. 49ers in Week 1

Identifying three potential X-factors for the Seattle Seahawks' defense against the San Francisco 49ers in Week 1.

Associated Press News on MSN · 1h

Seahawks hope to showcase improved running game when they open against 49ers’ young defense

The Seattle Seahawks struggled mightily to run the ball in 2024. The San Francisco 49ers faced significant challenges stopping opposing offenses altogether.

1hon MSN

Patrick Willis says 49ers will reach playoffs if this falls into place

A realistic position should see the 49ers make the playoffs. Though the front office is clearly taking a one-game-at-a-time ...

Niners Wire on MSN11d

49ers vs. Chargers highlights: San Francisco wins thrilling NFL preseason game

Brock Purdy, Christian McCaffrey, Trent Williams, Nick Bosa, Fred Warner, George Kittle and Deommodore Lenoir should all be ...

USA Today3y

49ers vs. Rams score: Los Angeles returns to Super Bowl with close win

The 49ers and Rams renew their NFC West rivalry with a trip to the Super Bowl at stake. Keep track of all the action in the conference title game.

38mon MSN

Seahawks vs. 49ers: 4 key matchups to watch in season opener

When the San Francisco 49ers visit the Seattle Seahawks, it will be much more than just a matchup between two rivals. As is ...

Niners Wire on MSN11d

Son of 49ers legend scores 1st ever touchdown in preseason game vs. Chargers

The San Francisco 49ers called on the son of a franchise legend to put away the Los Angeles Chargers in the preseason.

Sporting News on MSN1d

49ers radio station 2025: Channels, live streams, schedule to listen to San Francisco NFL game broadcasts

Greg Papa has been a staple of Bay Area sports for more than three decades, and his résumé just keeps getting longer. With the 49ers now under his belt, he’s the first broadcaster to have called games ...

20h

49ers’ Kyle Shanahan confirms Jauan Jennings’ Week 1 status vs. Seahawks

San Francisco 49ers head coach Kyle Shanahan says that Jauan Jennings is good to go for Sunday's season opener.

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