ComingSoon can exclusively reveal the trailer for Love, Danielle. Love, Danielle is a new dramedy movie about a woman who tests positive for a BRCA1 gene mutation, which then puts her at high risk of ...

Researchers from The University of Texas MD Anderson Cancer Center identified a new role for heat shock protein 90 (HSP90) in cancer predisposition and treatment resistance. Their discovery, published ...

Mutations in the BRCA1 gene that are either inherited (germline) or acquired (somatic) might not be key to the initiation of prostate cancer, as previously thought, suggests the first study of its ...

HSP90 buffers certain BRCA1 mutations, allowing them to persist in humans and promote resistance to PARP inhibitor treatments Low-dose HSP90 inhibition restored PARP inhibitor sensitivity in ...

Mutations in BRCA1 do not appear to contribute significantly to the risk of prostate cancer progression, according to DNA test results from 450 prostate cancer specimens. The findings suggest that ...

In women with BRCA1 mutations, hormonal contraceptives were associated with a significantly higher risk for breast cancer in a dose-response relationship, researchers reported in an observational ...

They are genes commonly associated with breast cancer in women, but in fact men who carry certain mutations in their BRCA1 or BRCA2 genes are at higher risk of developing certain types of cancer ...

RAD51-based assessment effectively identifies HER2-negative metastatic breast cancer patients likely to respond to olaparib, especially with BRCA1/2 or PALB2 variants. RAD51-low tumors showed a higher ...