For decades, scientists have known that motor proteins like kinesin-2 ferry vital cargo along microtubule "highways" inside cells. But how these molecular vehicles identify and bind to the right cargo ...
Zachary Gergely, Saad Ansari, Michele Jones, J. Richard McIntosh, and Meredith D. Betterton (2023). Journal of Cell Science136, jcs.260474. DOI: 10.1242/jcs.260474. Download. Kinesin-5 motors are ...
Inside neurons, motor proteins haul precious cargo, moving essential goods along thread-like roadways called microtubule tracks. This miniature highway system is vital for keeping neurons healthy: ...
Zachary Gergely, Michele Jones, Bojun Zhou, Cai Cash, J. Richard McIntosh, and Meredith D. Betterton (2023). Distinct regions of the kinesin-5 C-terminal tail are essential for mitotic spindle midzone ...
As organisms grow, live, and move through the world, they're subjected to an array of internal and external forces. Biological forms must be able to withstand the stresses of stretching and ...
Microtubule, a cytoskeletal filament, may function as a mechano-sensor to regulate intracellular transport by its motor protein, kinesin. Tension, flexure, or compression in the microtubule filament ...
Kinesin with vesicle is attached with two "feet" to the cell's microtubule. This is a safe and stable time period. The kinesin untethers its back foot and moves it forward. This is a vulnerable time ...
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