If you receive Microsoft Excel cannot access the file, There are several possible reasons error message you can use the following suggestions to resolve the issue.

Microsoft increased the power and range of its protections against these attacks through configurable limits on Excel's compatibility with specific file types, including some of Excel's own.

If you see The file couldn't open in protected view error while opening Microsoft Excel, the fixes listed in this post will help you.

Microsoft Excel will now disable blocked file types from workbook links by default The files will either fail to refresh or show a #BLOCKED error Other safety updates ...